NOT KNOWN DETAILS ABOUT PKRRATING

The activated enzyme then phosphorylates its major substrate, the translational initiation aspect eIF2α. The ensuing translational arrest blocks viral replication. PKR belongs to a conserved family of four protein kinases (PKR, PERK, GCN2, HRI) that all phosphorylate eIF2α in reaction to distinct stimuli12, triggering the built-in worry response1